Issue 0, 1983

Synthesis of [4,5-dehydroLeu2]- and [3,4-dehydropro6]-locust adipokinetic hormone

Abstract

The syntheses of [4,5-dehydroLeu2]- and [3,4-dehydroPro6]-locust adipokinetic hormone (LAKH) by the coupling of N-terminal hexapeptides prepared by the solid-phase method with a common C-terminal tetrapeptide synthesised in solution is described. At a dose level of 20 pmol, the former is at least as biologically active as LAKH, but the latter has only ca. 20% of the activity. Difficulties encountered in the incorporation of a 4,5-dehydroleucine residue into peptides are discussed.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1983, 723-729

Synthesis of [4,5-dehydroLeu2]- and [3,4-dehydropro6]-locust adipokinetic hormone

P. M. Hardy and P. W. Sheppard, J. Chem. Soc., Perkin Trans. 1, 1983, 723 DOI: 10.1039/P19830000723

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements