Solid-phase syntheses of the 31 residue peptide human β-endorphin on polar polyamide supports are described. Minimisation of acidic reaction conditions by replacement of the customary t-butoxycarbonyl and benzyl-based protecting groups by fluorenylmethoxycarbonyl and t-butyl gave a higher yield of purer product.
E. Atherton, M. Caviezel, H. Fox, D. Harkiss, H. Over and R. C. Sheppard, J. Chem. Soc., Perkin Trans. 1, 1983, 65 DOI: 10.1039/P19830000065
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