Artificial transport of amino-acid, oligopeptide, and related anions by macrocyclic polyamine-transition metal complex carriers

Abstract

Transition-metal complexes of the macrocyclic polyamine, 1,4,7,10-tetrabenzyl-1,4,7,10-tetra-azacyclododecane have been shown to be new and powerful ‘metallo-carriers’ for the transport of amino-acid and oligopeptide derivatives. Their transport properties are generally different from previously reported systems, and are essentially controlled by factors such as the nature of the central metal ion, and the antiport anion. The metallo-carriers described provide both a successful example of artificial oligopeptide transport, and a unique and interesting transport phenomenon across a chloroform liquid membrane.