All of the oxygen atoms in tylactone, a biosynthetic precursor of tylosin, are derived intact with their attached carbon atoms from C(1) of acetate, propionate, and butyrate, during its biosynthesis in cultures of a blocked mutant of Streptomyces fradiae.
D. O'Hagan, J. A. Robinson and D. L. Turner, J. Chem. Soc., Chem. Commun., 1983, 1337 DOI: 10.1039/C39830001337
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