Biosynthesis of the macrotetrolide antibiotics: an investigation using carbon-13 and oxygen-18 labelled acetate and propionate
Abstract
The biosynthesis of both enantiomers of nonactic acid, and of homononactic acid, has been studied using carbon-13 and oxygen-18 labelled acetate and propionate; this has shown the origin of the oxygen atoms in these building blocks and provided mechanistic information about their mode of biosynthesis and incorporation into the macrotetroloides.