The enzyme dihydrothymine dehydrogenase reduces boththe DNA base thymine and the anti-cancer drug 5-fluorouracil by overall transaddition of hydrogen, at the si-face at C-5 and the si-face at C-6.
D. Gani, P. B. Hitchcock and D. W. Young, J. Chem. Soc., Chem. Commun., 1983, 898 DOI: 10.1039/C39830000898
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