The use of 1-phenylthioprop-1-yne as an equivalent of phenylthiopropanone in aldol condensations
Abstract
Addition of 1-lithio-1-phenylthiopropa-1,2-diene (7) to ketones, followed by trifluoroacetylation, a 3,3-rearrangement, and methanolysis of the resulting dienol trifluoroacetates, leads to the C-3 homologated α-phenylthioenones (2a) in 31–66% overall yields.