Synthesis of the ultimate hepatocarcinogen, 2-acetylaminofluorene N-sulphate
Abstract
Reaction of N-hydroxy-2-acetylaminofluorene with dicyclohexylcarbodi-imide and H2SO4 yields 2-acetylaminofluorene N-sulphate, the presumed ultimate form of the hepatocarcinogen 2-acetylamino-fluorene.