Both acetylenic alcohols available from the attack of propynylmagnesium bromide on a steroidal C-22 aldehyde were utilised to generate a common γδ-unsaturated ester via a Claisen rearrangement. This ester was then converted into the title compound in a reaction sequence in which C-25 hydroxylation was achieved via oxygenation of the enolate anion of the C-26 ester function.
M. A. Gilhooly, D. S. Morris and D. H. Williams, J. Chem. Soc., Perkin Trans. 1, 1982, 2111 DOI: 10.1039/P19820002111
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