Aminosteroids. Part 8. Synthesis of the four isomeric 3,7-diamino-5α-pregnanes
Abstract
The preparation of the four isomeric 3,7-diamino-5α-pregnanes is reported. All four were prepared from pregnenolone by way of 7-oxo-5α-pregnan-3β-yl acetate. The equatorial amino-groups (3β- and 7β-) were formed by alkali-metal reduction of the oximes and the axial amino-groups by reduction of the azides with lithium aluminium hydride.