Synthesis of β-amino-acid peptides. Part 3. Preparation of racemic and chiral 3-aminobutyric acid derivatives and peptides using dihydro-oxazin-6-ones and conventional coupling reagents

Abstract

Peptides of R,S and S-3-aminobutyric acid have been prepared by conventional methods and also by using chiral oxazin-6-ones, the latter method proving to be superior because of the absence of the side-reactions. S-3-Aminobutyric acid derivatives were prepared by Arndt–Eistert homologation.