Convenient syntheses of 5-substituted 2- hydroxybenzoates and related reactions
Abstract
The enamine aidehydes RC(
CHNMe2)CHO (R = Et or Ph) were condensed with the bis-enolate CH2
C(O–)CH
C(O–)OEt to give the title aromatic compounds. Thus these products are available from the acetals R1CH2CH(OR2)2(R1= R2= Et; R1= Ph, R2= Me) in two steps. The Vilsmeier formylation of several derivatives of butanal was examined.
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