Osmotic coefficients of urea + guanidinium chloride mixtures in water at 298.15 K

Abstract

The osmotic coefficients of urea + guanidinium chloride mixtures in aqueous solutions have been determined at 298.15 K using the isopiestic vapour-pressure technique. A comparison is made between the results obtained and the corresponding results for other urea + salt aqueous solution mixtures. There is a correspondence between the urea + salt interactions and the tendency for the salts to destabilise protein structures.