Unusual effect of a mixed solvent on the asymmetric reduction of chiral α-keto-amides with sodium borohydride
Abstract
The mixed solvent tetrahydrofuran + methanol (99 : 1) was much more effective than the individual solvents in the asymmetric reduction of chiral α-keto-amides with sodium borohydride; this solvent effect in asymmetric induction is unprecedented.