Unprecedented aminative ring-opening reactions of [1,2,5]oxadiazolo[3,4-d] pyrimidine 1-oxides (pyrimidofuroxans)

Abstract

Reactions of 5-substituted 7-dimethlamino-[1,2,5]oxadiazolo[3,4-d]pyrimide 1-oxides with ammonia and amines results in unprecedented aminative furoxan ring-opening to the corresponging 4-amino-5-nitrosopyromidines, whereas [1,2,5]oxadiazolo[3,4-d]pyrimidin-7(6H)-one 1-oxide reacts with amines to afford 4-alkylaminomethylideneaminofuroxan-5-carboxamide derivatives.