Use of chiral lanthanide shift reagents for the nuclear magnetic resonance spectrometric determination of amphetamine enantiomers

Abstract

Synthesised tris(D,D-dicampholylmethanato)europium(III)[Eu(dcm)₃] and five commercially available chiral lanthanide shift reagents are used to resolve the nuclear magnetic resonance spectra of the enantiomeric C—CH₃ protons in D- and L-amphetamine. The chemical shift difference between these enantiomeric protons induced by the six shift reagents are evaluated for their prospective use in enantiomeric identification and determination. The base-line resolution induced by Eu(dcm)₃ renders the enantiomeric determination feasible without using any special quantitation technique.