The incorporation of DL-[β-14C]phenylalanine into podophyllotoxin (1) has been demonstrated. The subsequent stepwise degradation to 3′,4′-methylenedioxy-3,4,5-trimethoxybenzophenone bearing a 14C-carbonyl label establishes the in vivo synthesis of the carbon skeleton of this lignan.
D. C. Ayres, A. Farrow and B. G. Carpenter, J. Chem. Soc., Perkin Trans. 1, 1981, 2134 DOI: 10.1039/P19810002134
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