Withaperuvin and 4-deoxyphysalolactone, two new ergostane-type steroids from Physalis peruviana(Solanaceae)

Abstract

Withaperuvin (17S,20S,22R-4β,5β,6α,14α, 17β,20α_F-hexahydroxy-1-oxoergosta-2,24-dien-22,26-olide) was isolated from the roots of Physalis peruviana(Varanasi variety). The structure of the carbocyclic moiety was solved by X-ray analysis of the androstane derivative obtained by CrO₃ oxidation of withaperuvin-4,6-diacetate. The structure of the side-chain was inferred by spectral analysis. 4-Deoxyphysalolactone (17S,20S,22R-6α-chloro-5β,14α,17β,20α_F-tetrahydroxy-1-oxoergosta-2,24-dien-22,26-olide) is a minor sterodial constituent of the leaves of the same plant variety. Its structure was deduced by spectral analysis.