The enantiomers of the two diastereoisomers of 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin have been synthesised. Potent inhibition of platelet aggregation in this series is associated with the configuration corresponding to that in the natural inhibitors, such as prostaglandins E1 and D2.
M. A. Brockwell, A. G. Caldwell, N. Whittaker and M. J. Begley, J. Chem. Soc., Perkin Trans. 1, 1981, 706 DOI: 10.1039/P19810000706
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