Ultrasonic relaxations associated with aggregation in drugs

Abstract

An ultrasonic relaxation observed in aqueous solution of several drugs has been attributed to the perturbation of a monomer micelle equilibrium. In all these drugs the micellar aggregation number is in the range 6–11. The relaxation data have been analysed using the relaxation equations developed by Aniansson and Wall for normal surfactants having very high aggregation numbers. In addition, a numerical approach has been developed to analyse the data. The agreement between the two methods is excellent.