An in vitro model for the biosynthetic formation of the β-lactam ring system of penicillin is described in which reaction of N-t-butylhydrocinnamamide with di-t-butyl peroxide and Cu(o-phenanthroline)2Cl2 at 140 °C gave a small yield of the corresponding β-lactam; control experiments established that this did not derive from the corresponding β-chloroamide.
J. E. Baldwin and A. P. Davis, J. Chem. Soc., Chem. Commun., 1981, 1219 DOI: 10.1039/C39810001219
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