Issue 23, 1981

Utilization of the deuterium isotope effect to suppress enolization during alkylation of ketones

Abstract

A substantial enhancement in yield is observed in the reaction of enolizable ketones with the lithium salt of N,N-diethylbenzamide and N,N-diethyl-1-naphthamide when the hydrogen atoms α to the carbonyl group are replaced with deuterium.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1981, 1215-1216

Utilization of the deuterium isotope effect to suppress enolization during alkylation of ketones

S. A. Jacobs, C. Cortez and R. G. Harvey, J. Chem. Soc., Chem. Commun., 1981, 1215 DOI: 10.1039/C39810001215

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