SCHEDULED MAINTENANCE
ortho-Halogenated N-alkyl-N-acylbenzylamines can be cyclised to dihydroisoquinolones by reaction with KNH2 in liquid NH3 or lithium di-isopropylamide in tetrahydrofuran under photolytic and thermal conditions; the procedure has been employed to synthesize (±)-cherylline.
S. V. Kessar, P. Singh, R. Chawla and P. Kumar, J. Chem. Soc., Chem. Commun., 1981, 1074 DOI: 10.1039/C39810001074
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