Clavulanic acid derivatives and penicillin Vesters undergo Wittig reactions at the β-lactam carbonyl and the β-lactam can be regenerated by low-temperature ozonolysis; the crystal structure of one of the products is reported.
M. L. Gilpin, J. B. Harbridge, T. T. Howarth and T. J. King, J. Chem. Soc., Chem. Commun., 1981, 929 DOI: 10.1039/C39810000929
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