Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphonate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.
D. H. R. Barton, W. B. Motherwell and S. Z. Zard, J. Chem. Soc., Chem. Commun., 1981, 774 DOI: 10.1039/C39810000774
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