Mechanism of direct side-chain acylamination and aminoarylation of 2- and 4-picoline 1-oxides
Abstract
The isolation of radical coupling products and the observation of appropriate C.I.N.D.P. signals suggest that most of the title reactions proceed by homolysis of the anhydro-bases (4) or (9) followed by radical recombinations; a diaza-oxy-Cope rearrangement may still account for the formation of α-acylamination products.