Amino-acids and peptides, Part 44. Synthesis of protected peptides related to sequence 23–30 of bovine insulin B-chain

Abstract

Protected peptides related to the C-terminal octapeptide sequence (1) of the B-chain of bovine insulin, including those in which phenylalanine-24 and -25 have been replaced by alanine and by N-methylphenylalanine, have been synthesised by the picolyl ester method for use in the semi-synthesis of modified insulins. A further example of the usefulness of the piperidino-oxycarbonyl amino-protection group, cleaved selectively by sodium dithionite, is provided.