Further synthetic investigations in the eremophilane sesquiterpene group. Synthesis of (±)-isovalencenic acid, (±)-isovalencenol, and their (Z)-isomers, and experiments directed towards the synthesis of tessaric acid

Abstract

Stereospecific total syntheses of racemic isovalencenic acid and isovalencenol, two eremophilanoid sesquiterpenes of vetiver oil, along with their geometric isomers, are described. Details are also presented concerning a synthetic approach to tessaric acid, a similarly constituted natural sesquiterpene.