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Issue 0, 1980

Structural investigations of 3-acylpyrrolidine-2,4-diones by nuclear magnetic resonance spectroscopy and X-ray crystallography

Abstract

The 3-acylpyrrolidine-2,4-diones (tetramic acids) can exist in solution as pairs of internal tautomers and as a pair of external tautomers. The tautomer constitution of a number of bioactive 3-acylpyrrolidine-2,4-diones, e.g. α-cyclopiazonic acid (1) and tenuazonic acid (3), has been studied. The study was facilitated by 1H and 13C n.m.r. spectroscopy and single crystal X-ray crystallography. From these results the structures of a number of natural products containing the 3-acylpyrrolidine-2,4-dione unit have been revised.

Article information


J. Chem. Soc., Perkin Trans. 1, 1980, 1057-1065
Article type
Paper

Structural investigations of 3-acylpyrrolidine-2,4-diones by nuclear magnetic resonance spectroscopy and X-ray crystallography

M. J. Nolte, P. S. Steyn and P. L. Wessels, J. Chem. Soc., Perkin Trans. 1, 1980, 1057 DOI: 10.1039/P19800001057

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