Attempts to obtain N-(3-carboxy-2-pyridyl)glycine (5) from 2-chloro-3-cyanopyridine are described. The ring–chain tautomerism of certain N-(2-pyridyl)aminoacetaldehydes is discussed. Three preparations of N-3-(carboxy-2-pyridyl)aminoacetaldehyde (20) and its cyclisation to the zwitterionic imidazo[1,2-a]pyridinium-8-carboxylate (23) are given.
J. Parrick, R. Wilcox and A. H. Kelly, J. Chem. Soc., Perkin Trans. 1, 1980, 132 DOI: 10.1039/P19800000132
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