Issue 23, 1980

A convenient synthesis of 2,3,5,6-tetrahalogenopyridines and of 3,5-bis(alkylthio)pyridines from 2,6-diaminopyridine

Abstract

Controlled chlorination of 2,6-diaminopyridine (1) affords 2,6-diamino-3,5-dichloropyridine (2a) which is then bis(diazotised) to give 2,3,5,6-tetrachloropyridine (3a); similarly prepared are other 2,3,5,6-tetra(chloro/bromo)pyridines and 2,6-dichloro-3,5-bis(thiocyanato)pyridine (3h), from which 3,5-bis(alkylthio)pyridines are easily obtained.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1980, 1139-1140

A convenient synthesis of 2,3,5,6-tetrahalogenopyridines and of 3,5-bis(alkylthio)pyridines from 2,6-diaminopyridine

T. K. Chen and W. T. Flowers, J. Chem. Soc., Chem. Commun., 1980, 1139 DOI: 10.1039/C39800001139

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