Direct observation of an alkoxycarbonylamino acid O-acylisourea
Abstract
The reaction of equivalent amounts of benzyloxycarbonyl-L-valine and NN′-di-isopropylcarbodi-imide in deuteriochloroform at room temperature is very fast and clean giving an O-acylisourea adduct which is stable in solution for many hours and which has been characterised by n.m.r. spectroscopy.