Biosynthetic intermediates en route to mycophenolic acid in Penicillium brevicompactum
Abstract
The farnesyl phthalide (1; R2= Me, R3= H) and the mycophenolic acid prenylogue (4; R2= Me, R3= R4= H), but not the acyloin (3; R2= H or Me, R3= H), have been found by radiogas chromatography–mass spectrometric analysis of P. brevicompactum cultures that were active in mycophenolic acid biosynthesis.