A route to peptide analogues incorporating the replacement of an amide bond with a trans-carbon–carbon double bond is presented and applied to the synthesis of a Leu5–enkephalin analogue.
M. M. Hann, P. G. Sammes, P. D. Kennewell and J. B. Taylor, J. Chem. Soc., Chem. Commun., 1980, 234 DOI: 10.1039/C39800000234
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