Spectrophotometric method for the determination of procarbazine hydrochloride in capsules
Abstract
An accurate, sensitive and selective method for the determination of Natulan is proposed. The method is based on the oxidation of Natulan with 0.1 N ammonium cerium(IV) sulphate solution to formaldehyde and N-isopropyl benzamide-4-carboxaldehyde. The latter is separated as its 2,4-dinitrophenyl-hydrazone, which, when treated with ethanolic potassium hydroxide solution, gives a wine red colour. The method is applicable to microgram amounts and can be used successfully in the determination of Natulan in capsules. The stoicheiometry of 1 mol of Natulan to 6 mol of cerium(IV) has been shown through a titrimetric study.