Tetrahydroisoquinoline-1-carboxylic acids with a 6- or 7-hydroxy substituent undergo oxidative decarboxylation on treatment with horseradish peroxidase or fungal laccase to give high yields of the corresponding 3,4-dihydroisoquinolines. Attempts to apply this reaction to the formation of an aporphine were unsuccessful.
I. G. C. Coutts, M. R. Hamblin, E. J. Tinley and J. M. Bobbitt, J. Chem. Soc., Perkin Trans. 1, 1979, 2744 DOI: 10.1039/P19790002744
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