The total synthesis of 4,7-dihydroxy-9-methyl-10H-isobenzofuro[5,6-b][1,4]benzodioxepin-3.10(1H)-dione (variolaric acid)(1), a lichen depsidone, by functionalization of synthetic methyl 3,6-dimethoxy-1,8-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylate (12), is described.
R. Jongen, T. Sala and M. V. Sargent, J. Chem. Soc., Perkin Trans. 1, 1979, 2588 DOI: 10.1039/P19790002588
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