Isothiocyanate transposition through a retro-ene reaction: pyrolysis of acylthioureas
Abstract
Pyrolysis of N-aryl-N′-benzoylthioureas produces aryl isothiocyanates as the major product. This reaction has been used to prepare 4-isothiocyanato-4′-nitrodiphenylamine (7), a potent anthelmintic.