Fungal products. Part 21. Biosynthesis of the fungal metabolite, wortmannin, from [1,2-13C2]-acetate

Abstract

The ¹³C-n.m.r, spectrum of wortmannin, enriched with sodium [1,2-¹³C₂]-acetate by cultures of Peniciilium wortmannii, is consistent with the biogenesis of this metabolite via triterpenoid intermediates. Although the overall incorporation of ¹³C was low, ³³C–¹³C coupling was observed between carbon atoms derived from adjacent acetate units in addition to the expected coupling between carbon atoms in intact acetate units.