Reactions and syntheses with organometallic compounds. Part 6. A new synthesis of indole, quinoline, and benzazepine derivatives via arylnickel complexes

Abstract

o-Chloroaniline derivatives with an internal double bond were treated with MeMgBr (200 mol %) in the presence of a catalytic amount of NiCl₂(PPh₃)₂(1 mol %) to furnish heterocyclic compounds such as indole, quinoline, and even benzazepine derivatives in good yield.