The hydrolysis of some steroidal vicinal hydroxy-epoxides
Abstract
The hydrolysis of 1α-hydroxy-2α,3α-epoxy-, 1α-acetoxy-2α,3α-epoxy-, and 3α-acetoxy-1α,2α-epoxy-androstanes with hydrobromic acid led to the products of both diequatorial and diaxial cleavage of the epoxide. The hydrolysis of 3β-hydroxy- and 3β-acetoxy-1β,2β-epoxides led to diaxial products.