Issue 18, 1979

Regiospecific alkylation of phenols: ortho or para to α coupling in cyclization of bis-phenols via quinone methides

Abstract

Intramolecular alkylations of phenols by o- and p-hydroxybenzylic alcohols are achieved with high regioselectivity by heating the bis-magnesium salts of bis-phenols such as (2) and (5), which cyclise efficiently into aryl-indanols and aryltetralols.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1979, 788-789

Regiospecific alkylation of phenols: ortho or para to α coupling in cyclization of bis-phenols via quinone methides

W. S. Murphy and S. Wattanasin, J. Chem. Soc., Chem. Commun., 1979, 788 DOI: 10.1039/C39790000788

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