Multicolanic acid (3), and other 4-substituted tetronic acids (8), (9), (10), and (17) are conveniently synthesised from the corresponding unsubstituted parent compounds by protection of the enolic hydroxy-groups with pyrrolidine, and reaction of the carbanions of the resultant derivatives with either alkyl halides or aldehydes, followed by acid catalysed removal of the protecting groups.
S. C. M. Fell, J. Heaps and J. S. E. Holker, J. Chem. Soc., Chem. Commun., 1979, 81 DOI: 10.1039/C39790000081
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...