Applications of catalytic thermometric titrimetry to studies of molecular structure and reactivity. Part 1. Organic hydroxy groups

Abstract

Solutions of organic hydroxy compounds in acetic anhydride are used as indicator reagents in the catalytic thermometric titration of the weak base, quinoline, and the very weak base, caffeine, with perchloric acid in acetic acid. Comparisons of the titration curves are used to evaluate the relative reactivities of the hydroxy reagents. Consideration of these relative reactivities for hydroxy compounds of similar structure is used to establish relationships between reactivity and molecular environment of the hydroxy group.