A fully protected pteroyl-γ-L-glutamate has been prepared using the picolyl basic ester handle, in conjunction with C-terminal carboxy peptide elongation. By using highly purified pteroic acid the isolation of protected derivatives was readily accomplished. Additionally a number of new L-glutamic acid derivatives are described for the first time.
C. N. C. Drey and G. P. Priestley, J. Chem. Soc., Perkin Trans. 1, 1978, 800 DOI: 10.1039/P19780000800
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