Issue 8, 1978

A model folate synthesis incorporating the basic picolyl ester group

Abstract

A fully protected pteroyl-γ-L-glutamate has been prepared using the picolyl basic ester handle, in conjunction with C-terminal carboxy peptide elongation. By using highly purified pteroic acid the isolation of protected derivatives was readily accomplished. Additionally a number of new L-glutamic acid derivatives are described for the first time.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1978, 800-804

A model folate synthesis incorporating the basic picolyl ester group

C. N. C. Drey and G. P. Priestley, J. Chem. Soc., Perkin Trans. 1, 1978, 800 DOI: 10.1039/P19780000800

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