Biosynthesis of isocorydine (1,2,10-trimethoxy-6aα-aporphin-11-ol)
Abstract
The incorporation of (±)-nororientaline, (±)-norprotosinomenine, (±)-reticuline, and (±)-norlaudanidine into isocorydine in Annona squamosa has been studied, and the specific utilization of (±)-reticuline demonstrated. The evidence supports the direct ortho–ortho oxidative coupling of (+)-nor-reticuline to give the isocorydine nucleus.