Tetracycline studies. Part 6. 6- and 12a-Hydroxylation of 6-methylpretetramid
Abstract
Oxygenation of 6-methylpretetramid (1) in dimethylformamide–aqueous alkali resulted in specific hydroxylation at the 6- and 12a-positions. The molecular structure of the product (29) was established by degradation studies and by means of spectroscopic evidence.