Issue 20, 1978

Neighbouring carboxylate group participation in ester aminolysis in non-hydroxylic solvents. The n-butylaminolysis of aspirin in acetonitrile

Abstract

In acetonitrile the carboxylate group of aspirin anion has been found to assist the n-butylaminolysis of the neighbouring ester function with a mechanism changing from nucleophilic to concomitant nucleophilic and probably general base catalysis as the amine concentration is increased.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1978, 886-888

Neighbouring carboxylate group participation in ester aminolysis in non-hydroxylic solvents. The n-butylaminolysis of aspirin in acetonitrile

G. Guanti, S. Thea, C. Dell'Erba and F. Pero, J. Chem. Soc., Chem. Commun., 1978, 886 DOI: 10.1039/C39780000886

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