Alternative synthetic route to the cembrene skeleton
Abstract
The cembrene derivative (VI; Z = SO2Ph) has been prepared by coupling of the geranyl units (I) and (II) to give the seco-cembrene derivatives (IIIa) or (IIIb), followed by reduction (IIIa) or hydrolysis (IIIb), conversion into the bromide, (V; Y = Br), and ring closure with lithium di-isopropylamide.