The p-tolylmethylsulphonyl group for the protection of the ε-amino group of lysine, which is readily removed with anhydrous hydrogen fluoride but is strongly resistant to trifluoroacetic acid or dilute hydrogen chloride, can be applied to both solid-phase and solution synthesis of peptides.
T. Fukuda, C. Kitada and M. Fujino, J. Chem. Soc., Chem. Commun., 1978, 220 DOI: 10.1039/C39780000220
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